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Parameters Number of Divisions : size of the array Proportions : template of expected proportions in the two groups for each division

Data Columns : 2 columns for the 2 groups. Rows : Number of rows = Number of divisions x Number of reviews. Each set of rows (number of divisions) represents each consecutive observations in the same study Cells : each cell is the number of cases for that group for that array division for that review Click button to run program using example data, or replace example data with real data and click button to run.

Whitehead John (1992). The Design and Analysis of Sequential Clinical Trials (Revised 2nd. Edition) . John Wiley & Sons Ltd., Chichester, ISBN 0 47197550 8.